KissPeptin 10MG

Kisspeptin is a naturally occurring peptide that strongly regulates the hypothalamic–pituitary–gonadal (HPG) axis by stimulating GnRH release. A 10 mg preparation is an investigational/research-level dose (administration, frequency and effective dose vary widely by indication) and should only be used under medical or research supervision.

Primary benefits and uses

• Stimulates reproductive hormone release: acutely increases GnRH → LH and FSH secretion, useful to trigger egg maturation in assisted reproduction (IVF) and to test/restore HPG axis function.
• Fertility treatment support: used to induce oocyte maturation in certain IVF protocols with lower risk of ovarian hyperstimulation syndrome (OHSS) compared with hCG in selected patients.
• Evaluation of reproductive axis: diagnostic tool to assess central hypogonadism or GnRH reserve.
• Treatment of some forms of hypogonadism: investigational use to restore endogenous testosterone/estrogen production in men and women by reactivating the HPG axis.
• Potential sexual function effects: may increase libido and sexual responsiveness via restored sex-hormone production (investigational).
• Possible applications in PCOS and pregnancy-related disorders: experimental—may help re-regulate abnormal gonadotropin secretion in PCOS; research ongoing for other reproductive disorders.

Mechanism

• Binds GPR54 (KISS1R) on GnRH neurons → pulsatile GnRH release → pituitary LH/FSH rise → gonadal steroidogenesis and gametogenesis.

Administration and dosing

• Typical research/clinical protocols use intravenous bolus or infusion or subcutaneous dosing; effective doses vary from micrograms/kg to milligram-range depending on protocol. A straight “10 mg” dose is high compared with many published protocols and dosing must be individualized and supervised by specialists.
• Often given as single bolus to trigger ovulation or as repeated/infused doses to restore pulsatility.